Beneficial microbes hold great promise for the treatment of a wide range of immune and inflammatory disorders. In this issue of The EMBO Journal, Lightfoot and colleagues report how the food-grade bacterium Lactobacillus acidophilus helps the immune system to limit experimental colitis in mice through interaction between SIGNR3 and surface layer protein A (SlpA) in L. acidophilus. These results pave the way for future development of novel therapies for inflammatory diseases, including inflammatory bowel disease.
Geanncarlo Lugo-Villarino, Olivier Neyrolles. SIGNing a symbiotic treaty with gut microbiota. The EMBO journal. 2015 Apr 1;34(7):829-31
PMID: 25736375
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