Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

Both mutation and knockdown in mev-1 gene render Caenorhabditis elegans susceptibility to Enterococcus faecalis infection. However, the mechanisms by which of MEV-1 defects pathogen resistance remain unclear. Here we show that mev-1RNAi causes a dramatic decrease in oxidative stress and antioxidant enzyme expressions, thereby leading to increased E. faecalis accumulation in nematode intestine. Mitochondrial superoxide change after infection induced these oxidative responses through DAF-16 activity. All together, this highlights MEV-1 as a key regulatory component for determining genetic responsiveness to oxidant/antioxidant imbalance that is associated with innate immunity. Copyright © 2015 Elsevier Inc. All rights reserved.

Citation

Na Feng, Dejuan Zhi, Liyun Zhang, Jing Tian, Hui Ren, Chanhe Li, Hongmei Zhu, Hongyu Li. Molecular mechanisms of resistance to human pathogenic bacteria in Caenorhabditis elegans by MEV-1 mediated oxidative stress. Biochemical and biophysical research communications. 2015 Apr 10;459(3):481-7

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 25747713

View Full Text