Na Feng, Dejuan Zhi, Liyun Zhang, Jing Tian, Hui Ren, Chanhe Li, Hongmei Zhu, Hongyu Li
Biochemical and biophysical research communications 2015 Apr 10Both mutation and knockdown in mev-1 gene render Caenorhabditis elegans susceptibility to Enterococcus faecalis infection. However, the mechanisms by which of MEV-1 defects pathogen resistance remain unclear. Here we show that mev-1RNAi causes a dramatic decrease in oxidative stress and antioxidant enzyme expressions, thereby leading to increased E. faecalis accumulation in nematode intestine. Mitochondrial superoxide change after infection induced these oxidative responses through DAF-16 activity. All together, this highlights MEV-1 as a key regulatory component for determining genetic responsiveness to oxidant/antioxidant imbalance that is associated with innate immunity. Copyright © 2015 Elsevier Inc. All rights reserved.
Na Feng, Dejuan Zhi, Liyun Zhang, Jing Tian, Hui Ren, Chanhe Li, Hongmei Zhu, Hongyu Li. Molecular mechanisms of resistance to human pathogenic bacteria in Caenorhabditis elegans by MEV-1 mediated oxidative stress. Biochemical and biophysical research communications. 2015 Apr 10;459(3):481-7
PMID: 25747713
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