SUMO2 overexpression enhances the generation and function of interleukin-17-producing CD8⁺ T cells in mice.

Tae Joon Won, Yun-Jung Lee, Kyeong Eun Hyung, Eunyoung Yang, Uy Dong Sohn, Hae Young Min, Do Ik Lee, So-Young Park, Kwang Woo Hwang

Cellular signalling 2015 Jun

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Small ubiquitin-like modifier (SUMO) 2 is a small protein that controls the activity and stability of other proteins by SUMOylation. In this study, T cell-specific SUMO2 overexpressing transgenic mice were generated to study the effect of SUMO2 on T lymphocytes. SUMO2 overexpression promoted differentiation of interleukin (IL)-17-producing CD8(+) T cells, and significantly suppressed the growth of EL4 tumor cells in vivo. Moreover, the tumor tissue from SUMO2-overexpressing mice had higher interferon (IFN)-γ and granzyme B mRNA levels. Although SUMO2 overexpression did not increase IFN-γ or granzyme B production in cytotoxic T lymphocytes, IL-12 treatment restored and increased IFN-γ secretion in IL-17-producing CD8(+) T cells. SUMO2 overexpression also increased gene expression of chemokines, CCL4, and CXCL10, which attract cytotoxic T lymphocytes to tumor tissues. Additionally, SUMO2-overexpressing T cells exhibited increased STAT3 phosphorylation, implying a SUMO2 target which up-regulates STAT3 activity governing IL-17A-producing CD8(+) T cell differentiation and antitumor immune responses. Copyright © 2015. Published by Elsevier Inc.

Citation

Tae Joon Won, Yun-Jung Lee, Kyeong Eun Hyung, Eunyoung Yang, Uy Dong Sohn, Hae Young Min, Do Ik Lee, So-Young Park, Kwang Woo Hwang. SUMO2 overexpression enhances the generation and function of interleukin-17-producing CD8⁺ T cells in mice. Cellular signalling. 2015 Jun;27(6):1246-52