Influence of synthetic peptide of active GM-CSF center on hemopoiesis recovery in C57Bl/6 mice after exposure to fractionated radiation].

A V Akleev, G A Triapitsyna, A S Simbirtsev, A A Akleev, E A Priakhin, A V Zurochka

Radiatsionnaia biologiia, radioecologiia / Rossiĭskaia akademiia nauk 2014 Mar-Apr

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The research allowed evaluation of the influence exerted by synthetic peptide of the active center of granulocyte-macrophage colony-stimulating (GM-CSF) factor on hematopoiesis in mice both under normal physiological conditions of the animals, and during the period of post-exposure recovery of hematopoiesis. It has been demonstrated that a synthetic peptide of the active GM-CSF center is able to exert a stimulating effect on animals with radiation-induced hematopoiesis inhibition. A single injection of the preparation at a dose of 0.005 μg/g to female C57Bl/6 mice, which had been exposed to fractionated exposure at a dose of 10 Gy and developed inhibition of bone-marrow hematopoiesis and cytopenia, exerted a stimulating effect on the granulocyte and monocyte lineages of hemopoiesis. Injections of an active GM-CSF center peptide to irradiated animals did not influence the content of CFUs in thebone-marrow (BM), but they exerted a stimulating influence on the population of these cells in unexposed animals. No effect of the influence of the preparation on the development of extramedullary hematopoiesis in the spleen was observed in the irradiated mice. The study showed that a peptide active site GM-CSF is a promising drug in terms of its use for the treatment of radiation-induced myelosuppression.

Citation

A V Akleev, G A Triapitsyna, A S Simbirtsev, A A Akleev, E A Priakhin, A V Zurochka. Influence of synthetic peptide of active GM-CSF center on hemopoiesis recovery in C57Bl/6 mice after exposure to fractionated radiation]. Radiatsionnaia biologiia, radioecologiia / Rossiĭskaia akademiia nauk. 2014 Mar-Apr;54(2):117-26