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Fibrillarin is an essential protein that is well known as a molecular marker of transcriptionally active RNA polymerase I. Fibrillarin methyltransferase activity is the primary known source of methylation for more than 100 methylated sites involved in the first steps of preribosomal processing and required for structural ribosome stability. High expression levels of fibrillarin have been observed in several types of cancer cells, particularly when p53 levels are reduced, because p53 is a direct negative regulator of fibrillarin transcription. Here, we show fibrillarin domain conservation, structure and interacting molecules in different cellular processes as well as with several viral proteins during virus infection. © 2015 Société Française des Microscopies and Société de Biologie Cellulaire de France. Published by John Wiley & Sons Ltd.


Ulises Rodriguez-Corona, Margarita Sobol, Luis Carlos Rodriguez-Zapata, Pavel Hozak, Enrique Castano. Fibrillarin from Archaea to human. Biology of the cell / under the auspices of the European Cell Biology Organization. 2015 Jun;107(6):159-74

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PMID: 25772805

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