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Brain metastases represent a devastating complication of melanoma. Our understanding of the mechanisms driving metastasis to the brain is limited. PLEKHA5 functions as a regulator of brain metastasis in melanoma, and further investigation is warranted to explore the use of PLEKHA5 as a potential therapeutic target. ©2015 American Association for Cancer Research.

Citation

Sylvia C Eisele, Corey M Gill, Ganesh M Shankar, Priscilla K Brastianos. PLEKHA5: A Key to Unlock the Blood-Brain Barrier? Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 May 1;21(9):1978-80

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PMID: 25779946

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