Effect of dopamine D1 and D2 receptor blockade on the immunostimulating effect of δ1 opioid receptor agonist DPDPE in mice with different psychoemotional states].

It is established that activation of delta1 opioid receptors with their selective agonist DPDPE(100 μg/kg) significantly increases IgM immune response not only in C57BL/6J mice with unchanged psychoemotional state, but also in mice displaying aggressive or depressive-like behavior in the social stress model (10 days of agonistic confrontations). SCH-23390 (1.0 mg/kg), selective antagonist of dopamine D1 receptors, and selective D2 receptor blocker haloperidol (1 mg/kg) prevented the immunostimulating effect of DPDPE in animals not subjected to social stress. At the same time, both SCH-23390 and haloperidol did not affect DPDPE-induced immunostimulation in mice engaged in aggressive or depressive-like behaviors.

Citation

M A Cheĭdo, G V Idova. Effect of dopamine D1 and D2 receptor blockade on the immunostimulating effect of δ1 opioid receptor agonist DPDPE in mice with different psychoemotional states]. Eksperimental'naia i klinicheskaia farmakologiia. 2015;78(1):27-9

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PMID: 25826871

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