Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Substituted piperidines are emerging as important medicinally-active structural motifs. Here, we report highly stereoselective carbolithiation reactions of α-aryl piperidine enecarbamates that offer direct access to vicinally-substituted piperidine compounds. We have also demonstrated that the carbanion intermediates can be trapped with a carbon electrophile.


Timothy K Beng, Hironori Takeuchi, Manuel Weber, Richmond Sarpong. Stereocontrolled synthesis of vicinally functionalized piperidines by nucleophilic β-addition of alkyllithiums to α-aryl substituted piperidine enecarbamates. Chemical communications (Cambridge, England). 2015 May 4;51(36):7653-6

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 25845938

View Full Text