Metal-free nitrogenation of 2-acetylbiphenyls: expeditious synthesis of phenanthridines.

Conghui Tang, Yizhi Yuan, Ning Jiao

Organic letters 2015 May 1

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An intermolecular nitrogenation reaction toward the synthesis of phenanthridines has been developed. This metal-free protocol provides a novel nitrogen-incorporation transformation using azides as the nitrogen source. Phenanthridines, which are of great interest in pharmaceutical and medicinal chemistry, are synthesized efficiently in one step. Moreover, the byproducts derived from the Schmidt reaction are inhibited, which further demonstrated the high chemoselectivity of this transformation.

Citation

Conghui Tang, Yizhi Yuan, Ning Jiao. Metal-free nitrogenation of 2-acetylbiphenyls: expeditious synthesis of phenanthridines. Organic letters. 2015 May 1;17(9):2206-9