Synthesis of alkynes from vinyl triflates using tetrabutylammonium fluoride.

Masaru Okutani, Yuji Mori

Chemical & pharmaceutical bulletin 2015

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A convenient method for the preparation of alkynes and alkynyl esters from ketones and β-keto esters is described which involves the formation of vinyl triflates, followed by elimination with tetrabutylammonium fluoride trihydrate, to give alkynes. Unlike established elimination methods, the method requires neither a strong base nor anhydrous conditions.

Citation

Masaru Okutani, Yuji Mori. Synthesis of alkynes from vinyl triflates using tetrabutylammonium fluoride. Chemical & pharmaceutical bulletin. 2015;63(5):393-6