Iron-catalyzed C(sp(2))-H and C(sp(3))-H methylations of amides and anilides.

Karolina Graczyk, Tobias Haven, Lutz Ackermann

Chemistry (Weinheim an der Bergstrasse, Germany) 2015 Jun 8

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The so-called magic methyl effect significantly boosts the bioactivities and physical properties of pharmacologically active drugs. Direct introduction of the methyl group by CH activation was accomplished with a versatile iron catalyst, which enabled the CH methylation of (hetero)benzamides, anilides, alkenes, and even alkanes by triazole assistance in a chemo-, site- and diastereo-selective fashion. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Karolina Graczyk, Tobias Haven, Lutz Ackermann. Iron-catalyzed C(sp(2))-H and C(sp(3))-H methylations of amides and anilides. Chemistry (Weinheim an der Bergstrasse, Germany). 2015 Jun 8;21(24):8812-5