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    In difficult-to-treat asthmatics, uncontrolled despite a high level of therapy and followed for 3 years with a mean number of sputum samples/patient = 10, sputum eosinophilia (≥3%) was observed in 87% of all sputum samples. Persistent sputum eosinophilia is a characteristic of severe uncontrolled asthma.

    Citation

    Federico L Dente, Manuela Latorre, Federica Novelli, Silvana Cianchetti, Maria Laura Bartoli, Elena Bacci, Antonella Di Franco, Barbara Vagaggini, Alessandro Celi, Pierluigi Paggiaro. Can Sputum Eosinophilia Be a Constant Feature in Severe Refractory Asthmatics? A 3-Year Longitudinal Study. International archives of allergy and immunology. 2015;166(4):287-90

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    PMID: 25968565

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