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Human basic fetoprotein (BFP), found in fetal serum and tissue extracts as well as in extracts of various cancer tissues, has long been known as a marker protein for cancers; however, the primary sequence has not yet been reported. This paper describes the identification of BFP using the N- and C-terminal amino acid sequence tags (Ac-AALTRDPQFQ and QQREARVQ, respectively) clarified by mass spectrometry-based methods, and a terminal tag database (ProteinCarta). In this study, BFP was identified as glucose-6-phosphate isomerase (G6PI_HUMAN). Copyright © 2015 Elsevier B.V. All rights reserved.


Hiroki Kuyama, Akiyasu C Yoshizawa, Chihiro Nakajima, Mutsumi Hosako, Koichi Tanaka. Identification of human basic fetoprotein as glucose-6-phosphate isomerase by using N- and C-terminal sequence tags and terminal tag database. Journal of pharmaceutical and biomedical analysis. 2015 Aug 10;112:116-25

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PMID: 25978494

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