Experimental efficacy of anidulafungin against Aspergillus terreus species complex.

Marta Sanchis, Javier Capilla, Emilio Mayayo, Francisco J Pastor, Josep Guarro

Medical mycology 2015 Aug

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Whereas echinocandins are alternatives for the treatment of invasive aspergillosis, the efficacy of anidulafungin (AFG) against Aspergillus terreus infection has not yet been explored. We have evaluated the in vitro activity, as well as the in vivo efficacy of AFG in neutropenic mice infected by A. terreus species complex. Time-kill studies showed in vitro fungistatic activity of AFG against two strains. AFG at doses of 5 and 10 mg/kg/day significantly reduced the fungal load in kidney of mice, but only the higher dose was able to prolong survival. © The Author 2015. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Citation

Marta Sanchis, Javier Capilla, Emilio Mayayo, Francisco J Pastor, Josep Guarro. Experimental efficacy of anidulafungin against Aspergillus terreus species complex. Medical mycology. 2015 Aug;53(6):630-5