Facile synthesis of acridines via Pd(0)-diphosphine complex-catalyzed tandem coupling/cyclization protocol.

Ting-Jun Wang, Wen-Wen Chen, Yi Li, Ming-Hua Xu

Organic & biomolecular chemistry 2015 Jun 21

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A facile and efficient approach for the synthesis of a variety of acridines via the tandem coupling/cyclization of substituted 2-bromobenzaldehydes and anilines is described. The reaction can be accomplished with ease in the presence of a catalytic amount of Pd2(dba)3 and diphosphine ligand dppf, providing a broad range of substituted acridines in good to excellent yields (up to 99%). The Lewis acid, AlCl3, is required to promote the cyclization for less electron-rich anilines.

Citation

Ting-Jun Wang, Wen-Wen Chen, Yi Li, Ming-Hua Xu. Facile synthesis of acridines via Pd(0)-diphosphine complex-catalyzed tandem coupling/cyclization protocol. Organic & biomolecular chemistry. 2015 Jun 21;13(23):6580-6