New ambuic acid derivatives from the solid culture of Pestalotiopsis neglecta and their nitric oxide inhibitory activity.

Qiu-Yue Qi, Er-Wei Li, Jun-Jie Han, Yun-Fei Pei, Ke Ma, Li Bao, Ying Huang, Feng Zhao, Hong-Wei Liu

Scientific reports 2015

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Four new ambuic acid derivatives (1-4), and four known derivatives (5-8), were isolated from the solid culture of a plant pathogenic fungus Pestalotiopsis neglecta. Their structures were elucidated by extensive NMR experiments. The absolute configuration of the C-16 secondary alcohol in 1 was deduced via the CD data of the in situ formed [Rh2(OCOCF3)4] complex with the acetonide derivative of 1. The absolute configuration in 3 was assigned by comparison of the experimental and simulated electronic circular dichroism (ECD) spectrum. The NMR data of compound 5 was reported for the first time. In the nitric oxide (NO) inhibition assay, compounds 4, 6 and 7 showed inhibitory activity against the NO production in the lipopolysaccharide (LPS)-induced macrophage with IC50 values of 88.66, 11.20, and 20.80 µM, respectively.

Citation

Qiu-Yue Qi, Er-Wei Li, Jun-Jie Han, Yun-Fei Pei, Ke Ma, Li Bao, Ying Huang, Feng Zhao, Hong-Wei Liu. New ambuic acid derivatives from the solid culture of Pestalotiopsis neglecta and their nitric oxide inhibitory activity. Scientific reports. 2015;5:9958