Current radiosynthesis strategies for 5-HT2A receptor PET tracers.

Matthias M Herth, Gitte M Knudsen

Journal of labelled compounds & radiopharmaceuticals 2015 Jun 15

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Serotonin 2A receptors have been implicated in various psychophysiological functions and disorders such as depression, Alzheimer's disease, or schizophrenia. Therefore, neuroimaging of this specific receptor is of significant clinical interest, and it is not surprising that many attempts have been made to develop a suitable 5-HT2A R positron emission tomography-tracer. In this review, we give an overview on the precursor, reference compound synthesis, and the preparation of promising 5-HT2A R radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes. Copyright © 2015 John Wiley & Sons, Ltd.

Citation

Matthias M Herth, Gitte M Knudsen. Current radiosynthesis strategies for 5-HT2A receptor PET tracers. Journal of labelled compounds & radiopharmaceuticals. 2015 Jun 15;58(7):265-73