A Highly Stereoselective Metal-Free Hydrogenation of Diimines for the Synthesis of Cis-Vicinal Diamines.

A highly stereoselective metal-free hydrogenation of vicinal diimines has been successfully realized for the first time using 5-10 mol % of Piers' borane as a catalyst under mild conditions, and a variety of cis-1,2-diamines were obtained in 92-99% yields. The current work provides a novel and efficient approach for the synthesis of vicinal diamines.

Citation

Xiaxia Zhu, Haifeng Du. A Highly Stereoselective Metal-Free Hydrogenation of Diimines for the Synthesis of Cis-Vicinal Diamines. Organic letters. 2015 Jun 19;17(12):3106-9

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PMID: 26020680

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