The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior.

Andreas Stengel, Hiroshi Karasawa, Yvette Taché

Hormones and behavior 2015 Jul

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Somatostatin was discovered four decades ago as hypothalamic factor inhibiting growth hormone release. Subsequently, somatostatin was found to be widely distributed throughout the brain and to exert pleiotropic actions via interaction with five somatostatin receptors (sst1-5) that are also widely expressed throughout the brain. Interestingly, in contrast to the predominantly inhibitory actions of peripheral somatostatin, the activation of brain sst2 signaling by intracerebroventricular injection of stable somatostatin agonists potently stimulates food intake and independently, drinking behavior in rodents. The orexigenic response involves downstream orexin-1, neuropeptide Y1 and μ receptor signaling while the dipsogenic effect is mediated through the activation of the brain angiotensin 1 receptor. Brain sst2 activation is part of mechanisms underlying the stimulation of feeding and more prominently water intake in the dark phase and is able to counteract the anorexic response to visceral stressors. Published by Elsevier Inc.

Citation

Andreas Stengel, Hiroshi Karasawa, Yvette Taché. The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior. Hormones and behavior. 2015 Jul;73:15-22