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Using a [2 + 2 + 2] cycloaddition/Mitsunobu reaction sequence, a convenient synthesis to access new benzocyclotrimer analogues has been developed. The new receptors have the geometry and functionality capable of recognizing the tetramethylammonium ion in the gas phase and in solution.

Citation

Romen Carrillo, Michael J Hynes, Víctor S Martín, Tomás Martín, Fernando Pinacho Crisóstomo. Synthesis of New Benzocyclotrimer Analogues: New Receptors for Tetramethylammonium Ion Recognition. Organic letters. 2015 Jun 19;17(12):2912-5

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PMID: 26031658

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