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Highly Regioselective Halogenation of Pyridine N-Oxide: Practical Access to 2-Halo-Substituted Pyridines.
Ying Chen, Jinkun Huang, Tsang-Lin Hwang, Maosheng J Chen, Jason S Tedrow, Robert P Farrell, Matthew M Bio, Sheng Cui
Organic letters 2015 Jun 19Sizes of these terms reflect their relevance to your search.
A highly efficient and regioselective halogenation reaction of unsymmetrical pyridine N-oxide under mild conditions is described. The methodology provides a practical access to various 2-halo-substituted pyridines, which are pharmaceutically important intermediates.
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Ying Chen, Jinkun Huang, Tsang-Lin Hwang, Maosheng J Chen, Jason S Tedrow, Robert P Farrell, Matthew M Bio, Sheng Cui. Highly Regioselective Halogenation of Pyridine N-Oxide: Practical Access to 2-Halo-Substituted Pyridines. Organic letters. 2015 Jun 19;17(12):2948-51
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PMID: 26037223
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