Structure of the MarR family protein Rv0880 from Mycobacterium tuberculosis.

Yun Rong Gao, Na Feng, Tao Chen, De Feng Li, Li Jun Bi

Acta crystallographica. Section F, Structural biology communications 2015 Jun

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Rv0880 from the pathogen Mycobacterium tuberculosis is classified as a MarR family protein in the Pfam database. It consists of 143 amino acids and has an isoelectric point of 10.9. Crystals of Rv0880 belonged to space group P1, with unit-cell parameters a = 54.97, b = 69.60, c = 70.32 Å, α = 103.71, β = 111.06, γ = 105.83°. The structure of the MarR family transcription regulator Rv0880 was solved at a resolution of 2.0 Å with an R(cryst) and R(free) of 21.2 and 24.9%, respectively. The dimeric structure resembles that of other MarR proteins, with each subunit comprising a winged helix-turn-helix domain connected to an α-helical dimerization domain.

Citation

Yun Rong Gao, Na Feng, Tao Chen, De Feng Li, Li Jun Bi. Structure of the MarR family protein Rv0880 from Mycobacterium tuberculosis. Acta crystallographica. Section F, Structural biology communications. 2015 Jun;71(Pt 6):741-5