Shal-type (Kv4.x) potassium channel pore blockers from scorpion venoms.

Pierre Edouard Bougis, Marie-France Martin-Eauclaire

Sheng li xue bao : [Acta physiologica Sinica] 2015 Jun 25

filter terms:

Voltage-gated potassium channels (Kv4.1, Kv4.2 and Kv4.3) encoded by the members of the KCND/Kv4 (Shal) channel family mediate the native, fast inactivating (A-type) K(+) current (IA) described both in heart and neurons. This IA current is specifically blocked by short scorpion toxins that belong to the α-KTx15 subfamily and which act as pore blockers, a different mode of action by comparison to spider toxins known as gating modifiers. This review summarizes our present chemical and pharmacological knowledge on the α-KTx15 toxins.

Citation

Pierre Edouard Bougis, Marie-France Martin-Eauclaire. Shal-type (Kv4.x) potassium channel pore blockers from scorpion venoms. Sheng li xue bao : [Acta physiologica Sinica]. 2015 Jun 25;67(3):248-54