A red-emitting ratiometric fluorescent probe based on a benzophosphole P-oxide scaffold for the detection of intracellular sodium ions.

Masayasu Taki, Hiroaki Ogasawara, Hiroshi Osaki, Aiko Fukazawa, Yoshikatsu Sato, Kimi Ogasawara, Tetsuya Higashiyama, Shigehiro Yamaguchi

Chemical communications (Cambridge, England) 2015 Jul 28

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We disclose the development of a ratiometric fluorescent probe based on a benzophosphole P-oxide and its application for the detection of intracellular Na(+) ions. Excitation by visible light induced red emission from this probe in water, which was subjected to a hypsochromic shift upon complexation with Na(+). Based on this change, a ratiometric analysis enabled us to visualise changes in the Na(+) concentration in living mammalian cells.

Citation

Masayasu Taki, Hiroaki Ogasawara, Hiroshi Osaki, Aiko Fukazawa, Yoshikatsu Sato, Kimi Ogasawara, Tetsuya Higashiyama, Shigehiro Yamaguchi. A red-emitting ratiometric fluorescent probe based on a benzophosphole P-oxide scaffold for the detection of intracellular sodium ions. Chemical communications (Cambridge, England). 2015 Jul 28;51(59):11880-3