Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Natural killer (NK) cells have traditionally been considered nonspecific components of innate immunity, but recent studies have shown features of antigen-specific memory in mouse NK cells. However, it has remained unclear whether this phenomenon also exists in primates. We found that splenic and hepatic NK cells from SHIV(SF162P3)-infected and SIV(mac251)-infected macaques specifically lysed Gag- and Env-pulsed dendritic cells in an NKG2-dependent fashion, in contrast to NK cells from uninfected macaques. Moreover, splenic and hepatic NK cells from Ad26-vaccinated macaques efficiently lysed antigen-matched but not antigen-mismatched targets 5 years after vaccination. These data demonstrate that robust, durable, antigen-specific NK cell memory can be induced in primates after both infection and vaccination, and this finding could be important for the development of vaccines against HIV-1 and other pathogens.


R Keith Reeves, Haiying Li, Stephanie Jost, Eryn Blass, Hualin Li, Jamie L Schafer, Valerie Varner, Cordelia Manickam, Leila Eslamizar, Marcus Altfeld, Ulrich H von Andrian, Dan H Barouch. Antigen-specific NK cell memory in rhesus macaques. Nature immunology. 2015 Sep;16(9):927-32

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 26193080

View Full Text