Keratinocyte growth factor receptor: a therapeutic target in solid cancer.

Liu Hong, Yu Han, Jinqiang Liu, Daiming Fan

Expert opinion on therapeutic targets 2015

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The treatment effects of advanced solid cancer are unsatisfactory, and novel therapeutic approaches are much needed. Keratinocyte growth factor receptor (KGFR) is a receptor tyrosine kinase that is primarily localized on epithelial cells. KGFR may play important roles in epithelial cell proliferation and differentiation, epithelial wound repair, embryonic development, immunity, tumor formation and development. This review summarizes the expression, function and mechanism of KGFR in solid cancer, and analyzes its value for the cancer therapy. Furthermore, this study discusses the limitations of KGFR-based therapy, and envisages future developments in the clinical applications of KGFR. KGFR may function as an ideal therapeutic target for solid cancer. Continued basic investigation of KGFR-mediated pathways will push insight into the novel strategies of target therapy. More in vivo studies and clinical trials should be performed to promote the translational bridging of the latest research into clinical application.

Citation

Liu Hong, Yu Han, Jinqiang Liu, Daiming Fan. Keratinocyte growth factor receptor: a therapeutic target in solid cancer. Expert opinion on therapeutic targets. 2015;19(10):1411-8