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This review discusses the pathogenic role of autoantibodies (autoAB) to excitatory and inhibitory neurotransmitters glutamate, GABA and their receptors in the pathogenesis of epilepsy. The data of clinical and experimental studies show that glutamate AMPA and NMDA- receptors autoAB and GABA receptors autoAB in high titers are highly pathogenic, causing a significant decrease of the density of the receptors and contribute the neuronal death. Discusses the results of experimental data about of the anticonvulsant action of glutamate antibodies (AT) and opposite proconvulsant effect of GABA antibodies in different models of epileptic activity.

Citation

L A Vetrile, M N Karpova, L V Kuznetzova. Autoantibodies to glutamate, GABA and their receptors in epilepsy]. Patologicheskaia fiziologiia i èksperimental'naia terapiia. 2015 Jan-Mar;59(1):90-8

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PMID: 26226695

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