Cu-Catalyzed direct cyanation of terminal alkynes with AMBN or AIBN as the cyanation reagent.

Guangwei Rong, Jincheng Mao, Yang Zheng, Ruwei Yao, Xinfang Xu

Chemical communications (Cambridge, England) 2015 Sep 18

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A Cu-catalyzed direct cyanation of terminal alkynes was reported with broad substrate generality in moderate to high yield, and AMBN (azobisisoamylonitrile)/AIBN (azobisisobutyronitrile) were used as less toxic and effective cyanating sources in open air. Interestingly, addition products were selectively achieved as the major product under the same conditions in argon.

Citation

Guangwei Rong, Jincheng Mao, Yang Zheng, Ruwei Yao, Xinfang Xu. Cu-Catalyzed direct cyanation of terminal alkynes with AMBN or AIBN as the cyanation reagent. Chemical communications (Cambridge, England). 2015 Sep 18;51(72):13822-5