Secondary corneal amyloidosis after perforating corneal trauma: A series of 5 cases and review of the literature.

Solin Saleh, Seymour Brownstein, Joshua S Manusow, André Jastrzebski, Kay Lam, Joseph W Sassani, George Mintsioulis, Steven M Gilberg

Survey of ophthalmology 2015 Nov-Dec

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We retrospectively reviewed the clinical and surgical histories of 5 patients with traumatic secondary corneal amyloidosis, a relatively rare sequela of nonsurgical and surgical perforating corneal trauma. Four had history of nonsurgical trauma, and 1 had surgical trauma to the cornea. Three specimens were obtained by penetrating keratoplasties and 2 by excision of the cornea during evisceration of the ocular contents. All the corneal specimens showed full-thickness scars of a prior perforating wound with congophilic amyloid deposits that exhibited apple-green birefringence under polarized light and dichroism. All cases had variable degrees of predominantly chronic nongranulomatous inflammation. Ultrastructural examination in 1 patient disclosed 8-nm diameter fibrils in disarray, consistent with amyloid. Amyloid P immunostaining was positive in all 3 patients tested for this protein. Copyright © 2015 Elsevier Inc. All rights reserved.

Citation

Solin Saleh, Seymour Brownstein, Joshua S Manusow, André Jastrzebski, Kay Lam, Joseph W Sassani, George Mintsioulis, Steven M Gilberg. Secondary corneal amyloidosis after perforating corneal trauma: A series of 5 cases and review of the literature. Survey of ophthalmology. 2015 Nov-Dec;60(6):590-5