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In the present study, we obtain a mouse anti-porcine complement receptor type 1 (CR1)-like monoclonal antibody (McAb) and use this McAb to verify the existence of CR1-like protein on porcine erythrocytes. Our results confirm that CR1-like protein is localized on the surface of porcine erythrocytes. Mouse immunoglobulin G inhibited the binding of serum-opsonized green fluorescent protein-expressing Escherichia coli to porcine erythrocytes. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis indicates that CR1-like McAb reacts with biochemically-purified porcine erythrocyte membrane fractions, with a clear band at 135 kDa to 140 kDa. We postulate that the 135 kDa to 140 kDa membrane protein is the equivalent of the porcine erythrocyte CR1-like protein.


Wei Yin, Jiaoyan Cui, Junbing Jiang, Junxing Zhao, Kuohai Fan, Na Sun, Zhiwei Wang, Yaogui Sun, Haili Ma, Hongquan Li. The immune adherence receptor CR1-like existed on porcine erythrocytes membrane. Scientific reports. 2015;5:13290

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PMID: 26268676

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