Rubella seronegativity in antenatal screening - Is it influenced by the introduction of universal childhood rubella immunization?

Terence T Lao, Daljit S Sahota, Lai-Wa Law, Tak-Yeung Leung

Vaccine 2015 Sep 11

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This study examined the impact of rubella immunization, implemented in Hong Kong in phases since 1978, on antenatal rubella serological status in Chinese women. In a retrospective cohort study, the incidence of antenatal rubella seronegative status in our parturients managed from 1998 to 2013 was analyzed by their year-of-birth as follows: <1965 (no childhood immunization), 1965-1982 (single dose at Primary 6), and ≥1983 (two doses at age 12 months and 12 years), adjusting for other factors including age, parity, body mass index, place-of-birth status and hepatitis B surface antigen (HBsAg) status. Rubella seronegativity decreased from 12.9%, 10.5%, to 9.8% respectively, and correlated inversely (P<0.001) with year-of-birth cohorts. Despite similar demographic profiles, this correlation was found only in Hong-Kong-born women (from 12.6%, 7.5% to 6.5% respectively), who also had significant lower incidences of rubella seronegativity (OR 0.73, 0.31 and 0.29 respectively) and HBsAg seropositivity (OR 1.09, 0.63 and 0.48 respectively) than China-born women. On regression analysis, rubella seronegativity was actually significantly increased following the implementation of immunization (aOR 1.20) while it was the reverse for non-residents (aOR 0.61). Although rubella seronegativity decreased with immunization, the effect was less than expected when adjusted for other risk factors. Copyright © 2015 Elsevier Ltd. All rights reserved.

Citation

Terence T Lao, Daljit S Sahota, Lai-Wa Law, Tak-Yeung Leung. Rubella seronegativity in antenatal screening - Is it influenced by the introduction of universal childhood rubella immunization? Vaccine. 2015 Sep 11;33(38):4776-81