Gorham's disease of the proximal tibia successfully treated with local administration of OK-432, followed by reconstruction with distraction osteogenesis: a case report.

Eiki Yamagishi, Akira Takeda, Shinichi Konno, Koichiro Takeda, Seita Hagino, Michiyuki Hakozaki

Journal of pediatric orthopedics. Part B 2016 Jan

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Gorham's disease (GD) is a rare and intractable disease characterized by marked progression of osteolysis associated with lymphangioma and/or hemangioma. Here, we describe a case of GD of the proximal tibia occurring in a 10-year-old boy. Although we could not correctly diagnose it at first, we finally diagnosed him as having GD. Progression of osteolysis of the tibia stopped 3 months after the local administration of OK-432. Thereafter, the huge bone defect with varus and extension deformity was reconstructed successfully by distraction osteogenesis using the Ilizarov method. The present case suggests that local administration of OK-432, followed by distraction osteogenesis is a treatment option for GD.

Citation

Eiki Yamagishi, Akira Takeda, Shinichi Konno, Koichiro Takeda, Seita Hagino, Michiyuki Hakozaki. Gorham's disease of the proximal tibia successfully treated with local administration of OK-432, followed by reconstruction with distraction osteogenesis: a case report. Journal of pediatric orthopedics. Part B. 2016 Jan;25(1):48-53