MDA-9/Syntenin Control.

Julie V Philley, Anbarasu Kannan, Santanu Dasgupta

Journal of cellular physiology 2016 Mar

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MDA-9/Syntenin is a small PDZ domain containing scaffolding protein with diverse array of functions regulating membrane trafficking, cell adhesion, neural, and synaptic development, ubiquitination, and exosome biogenesis. An appreciable number of studies also established a pivotal role of MDA-9/Syntenin in cancer development and progression. In this review, we will discuss the dynamic role of MDA-9/Syntenin in regulating normal and abnormal fate of various cellular processes. © 2015 Wiley Periodicals, Inc.