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A 30-year old woman was referred to our department with symptomatic breast cancer at 35 weeks gestation. Genetic testing revealed a pathogenic BRCA2 mutation. Labour was induced at 38 weeks. Mastectomy and axillary clearance were performed with a view to adjuvant chemotherapy, radiation and hormonal therapy. Multidisciplinary involvement is crucial for management of BRCA-associated breast cancer, especially in the context of pregnancy. Bilateral mastectomy may be indicated given the increased risk of ipsilateral and contralateral breast cancers. Tamoxifen may lower contralateral breast cancer risk in those in whom risk-reducing surgery is not performed.


C Nf Leidhin, A Heeney, C Connolly, N Swan, A Foster, J Geraghty. A Rare Case of BRCA2-Associated Breast Cancer in Pregnancy. Irish medical journal. 2015 Jul-Aug;108(7):217-8

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PMID: 26349355

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