Annexin A7 modulates BAG4 and BAG4-binding proteins in mitochondrial apoptosis.

Annexin A7 caused an anti-apoptosis phenotype in mouse hepatocarcinoma cells. Yet, the underlying mechanism remains unclear. In this study, we found that Annexin A7 had an inhibitory effect on the mitochondrial Cytochrome C release and Caspase-3 cleavage. Furthermore, Annexin A7 was identified to form a complex with BAG4 which is a negative regulator of apoptosis. Moreover, Annexin A7 was positively correlated with the protein levels of BAG4, Hsp70 and Bcl-2. Both Hsp70 and Bcl-2 bind BAG4 and inhibit Cytochrom C dependent activation of Caspase-3. Taken together, our study indicated Annexin A7 modulated BAG4 and BAG4-binding proteins in mitochondrial apoptosis. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

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Yue Du, Yuhong Huang, Yue Gao, Bo Song, Jun Mao, Lina Chen, Lulu Bai, Jianwu Tang. Annexin A7 modulates BAG4 and BAG4-binding proteins in mitochondrial apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2015 Aug;74:30-4

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PMID: 26349959

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