Suppression of ITGB4 Gene Expression in PC-3 Cells with Short Interfering RNA Induces Changes in the Expression of β-Integrins Associated with RGD-Receptors.

E N Knyazev, K M Nyushko, B Ya Alekseev, T R Samatov, M Yu Shkurnikov

Bulletin of experimental biology and medicine 2015 Aug

filter terms:

We studied the effect of transfection of PC-3 prostate cancer cells with a plasmid encoding shRNA complimentary to a fragment of integrin β4 (ITGB4). The results attest to considerable changes in the transcriptome of transfected cells. For instance, compensatory changes in the expression of integrin family genes were found.

Citation

E N Knyazev, K M Nyushko, B Ya Alekseev, T R Samatov, M Yu Shkurnikov. Suppression of ITGB4 Gene Expression in PC-3 Cells with Short Interfering RNA Induces Changes in the Expression of β-Integrins Associated with RGD-Receptors. Bulletin of experimental biology and medicine. 2015 Aug;159(4):541-5