Quercetin promotes neurite growth through enhancing intracellular cAMP level and GAP-43 expression.

The present study was designed to investigate the role of quercetin on neurite growth in N1E-115 cells and the underlying mechanisms. Quercetin was evaluated for its effects on cell numbers of neurites, neurite length, intracellular cAMP content, and Gap-43 expression in N1E-115 cells in vitro by use of microscopy, LANCE(tm) cAMP 384 kit, and Western blot analysis, respectively. Our results showed that quercetin could increase the neurite length in a concentration-dependent manner, but had no effect on the numbers of cells. Quercetin significantly increased the expression of cellular cAMP in a time- and concentration-dependent manner. The Gap-43 expression was up-regulated in a time-dependent manner. In conclusion, quercetin could promote neurite growth through increasing the intracellular cAMP level and Gap-43 expression. Copyright © 2015 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

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Ming-Ming Chen, Zhi-Qi Yin, Lu-Yong Zhang, Hong Liao. Quercetin promotes neurite growth through enhancing intracellular cAMP level and GAP-43 expression. Chinese journal of natural medicines. 2015 Sep;13(9):667-72

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PMID: 26412426

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