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We established a catalog of the mouse gut metagenome comprising ∼2.6 million nonredundant genes by sequencing DNA from fecal samples of 184 mice. To secure high microbiome diversity, we used mouse strains of diverse genetic backgrounds, from different providers, kept in different housing laboratories and fed either a low-fat or high-fat diet. Similar to the human gut microbiome, >99% of the cataloged genes are bacterial. We identified 541 metagenomic species and defined a core set of 26 metagenomic species found in 95% of the mice. The mouse gut microbiome is functionally similar to its human counterpart, with 95.2% of its Kyoto Encyclopedia of Genes and Genomes (KEGG) orthologous groups in common. However, only 4.0% of the mouse gut microbial genes were shared (95% identity, 90% coverage) with those of the human gut microbiome. This catalog provides a useful reference for future studies.


Liang Xiao, Qiang Feng, Suisha Liang, Si Brask Sonne, Zhongkui Xia, Xinmin Qiu, Xiaoping Li, Hua Long, Jianfeng Zhang, Dongya Zhang, Chuan Liu, Zhiwei Fang, Joyce Chou, Jacob Glanville, Qin Hao, Dorota Kotowska, Camilla Colding, Tine Rask Licht, Donghai Wu, Jun Yu, Joseph Jao Yiu Sung, Qiaoyi Liang, Junhua Li, Huijue Jia, Zhou Lan, Valentina Tremaroli, Piotr Dworzynski, H Bjørn Nielsen, Fredrik Bäckhed, Joël Doré, Emmanuelle Le Chatelier, S Dusko Ehrlich, John C Lin, Manimozhiyan Arumugam, Jun Wang, Lise Madsen, Karsten Kristiansen. A catalog of the mouse gut metagenome. Nature biotechnology. 2015 Oct;33(10):1103-8

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PMID: 26414350

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