Elements as Direct Feedstocks for Organic Synthesis: Fe/I2/O2 for Diamination of 2-Cyclohexenones with 2-Aminopyrimidine and 2-Aminopyridines.

Thanh Binh Nguyen, Mathilde Corbin, Pascal Retailleau, Ludmila Ermolenko, Ali Al-Mourabit

Organic letters 2015 Oct 16

filter terms:

Elements as feedstocks for organic synthesis, the trio of metallic iron, molecular iodine, and dioxygen, were found to be an excellent tool for oxidative regioselective diamination of conjugated enones with 2-aminopyrimidine (a guanidine surrogate) and 2-aminopyridines leading to unaromatized coupled products in moderate to good yields.

Citation

Thanh Binh Nguyen, Mathilde Corbin, Pascal Retailleau, Ludmila Ermolenko, Ali Al-Mourabit. Elements as Direct Feedstocks for Organic Synthesis: Fe/I2/O2 for Diamination of 2-Cyclohexenones with 2-Aminopyrimidine and 2-Aminopyridines. Organic letters. 2015 Oct 16;17(20):4956-9