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Whether aldosterone activates the G-protein-coupled estrogen receptor (GPER) has been questioned, recently, in the name of Copernicus. However, for G-protein-coupled receptors (GPCRs) multiple hormone activators are common. Further, studies in mineralocorticoid receptor (MR)-deficient systems, with pharmacological GPER-selective antagonists or regulation of GPER expression, consistently show that some aldosterone effects can be GPER mediated. Copyright © 2015 Elsevier Ltd. All rights reserved.


Ross D Feldman, Lee E Limbird. Copernicus Revisited: Overturning Ptolemy's View of the GPER Universe. Trends in endocrinology and metabolism: TEM. 2015 Nov;26(11):592-4

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PMID: 26482875

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