An approach to construct enantiopure complex natural product-like frameworks, including the first reported synthesis of a C17 oxygenated taxoid scaffold, is presented. A palladium-catalyzed C-C activation/cross-coupling is utilized to access these structures in a short sequence from (+)-carvone; the scope of this reaction is explored.
Manuel Weber, Kyle Owens, Ahmad Masarwa, Richmond Sarpong. Construction of Enantiopure Taxoid and Natural Product-like Scaffolds Using a C-C Bond Cleavage/Arylation Reaction. Organic letters. 2015 Nov 6;17(21):5432-5
PMID: 26485318
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