Estimating Relatedness in the Presence of Null Alleles.

Studies of genetics and ecology often require estimates of relatedness coefficients based on genetic marker data. However, with the presence of null alleles, an observed genotype can represent one of several possible true genotypes. This results in biased estimates of relatedness. As the numbers of marker loci are often limited, loci with null alleles cannot be abandoned without substantial loss of statistical power. Here, we show how loci with null alleles can be incorporated into six estimators of relatedness (two novel). We evaluate the performance of various estimators before and after correction for null alleles. If the frequency of a null allele is <0.1, some estimators can be used directly without adjustment; if it is >0.5, the potency of estimation is too low and such a locus should be excluded. We make available a software package entitled PolyRelatedness v1.6, which enables researchers to optimize these estimators to best fit a particular data set. Copyright © 2016 by the Genetics Society of America.

Citation

Kang Huang, Kermit Ritland, Derek W Dunn, Xiaoguang Qi, Songtao Guo, Baoguo Li. Estimating Relatedness in the Presence of Null Alleles. Genetics. 2016 Jan;202(1):247-60

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PMID: 26500259

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