Haemoglobin content modulated deformation dynamics of red blood cells on a compact disc.

Shantimoy Kar, Uddipta Ghosh, Tapas Kumar Maiti, Suman Chakraborty

Lab on a chip 2015 Dec 21

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We investigate the deformation characteristics of red blood cells (RBCs) on a rotating compact disc platform. Our study brings out the interplay between haemoglobin content and RBC deformability in a centrifugally actuated microfluidic environment. We reveal that RBC deformations follow the similar trend of principal stress distributed throughout the radial direction, rendering an insight into the mechano-physical processes involved. This study can be used as a diagnostic marker to determine haematological disorders in diseased blood samples tested on compact disc based microfluidic platforms.

Citation

Shantimoy Kar, Uddipta Ghosh, Tapas Kumar Maiti, Suman Chakraborty. Haemoglobin content modulated deformation dynamics of red blood cells on a compact disc. Lab on a chip. 2015 Dec 21;15(24):4571-7