Proteolysis of His-Phe-Arg-Trp-Pro-Gly-Pro in the blood and brain of rats in vivo.

K V Shevchenko, I Yu Nagaev, V N Babakov, L A Andreeva, V P Shevchenko, A S Radilov, N F Myasoedov

Doklady. Biochemistry and biophysics 2015

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The kinetics of the content of His-Phe-Arg-Trp-Pro-Gly-Pro (ACTH (6-9)PGP) and its hydrolysis products in the blood and brain of rats in the case of intranasal administration and intravenous injection of tritiated ACTH(6-9)PGP was studied. The parameters of bioavailability of ACTH(6-9)PGP administered intranasally were higher, indicating certain prospects in the intranasal application in clinical practice. We also found that the factor that determines ACTH(6-9)PGP proteolysis in experiments both in vivo and in vitro is aminopeptidases. The main products of ACTH(6-9)PGP during its metabolism in rats are short peptides and amino acids.

Citation

K V Shevchenko, I Yu Nagaev, V N Babakov, L A Andreeva, V P Shevchenko, A S Radilov, N F Myasoedov. Proteolysis of His-Phe-Arg-Trp-Pro-Gly-Pro in the blood and brain of rats in vivo. Doklady. Biochemistry and biophysics. 2015;464:301-4