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Modulation of nuclear PI-PLCbeta1 during cell differentiation.

Lucio Cocco, Lucia Manzoli, Irene Faenza, Giulia Ramazzotti, Yong Ryoul Yang, James A McCubrey, Pann-Ghill Suh, Matilde Y Follo

Advances in biological regulation 2016 Jan


filter terms:
  • behavior (1)
  • cell (2)
  • Cyclin D3 (2)
  • hematopoiesis (2)
  • human cells (1)
  • myoblasts (1)
  • myogenesis (1)
  • osteogenesis (1)
  • PLCbeta1 (7)
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    PI-PLCbeta1 plays an important role in cell differentiation, and particularly in myogenesis, osteogenesis and hematopoiesis. Indeed, the increase of PI-PLCbeta1, along with Cyclin D3, has been detected in C2C12 mouse myoblasts induced to differentiate, as well as in human cells obtained from myotonic dystrophy. Also in the case of osteogenic differentiation there is a specific induction of PI-PLCbeta1, but in this case the role of PI-PLCbeta1 seems to be independent from Cyclin D3, so that a different mechanism could be involved. As for the hematopoietic system, PI-PLCbeta1 has a peculiar behavior: it increases during myeloid differentiation and decreases during erythroid differentiation, thus confirming the role of PI-PLCbeta1 as a modulator of hematopoiesis. Copyright © 2015 Elsevier Ltd. All rights reserved.

    Citation

    Lucio Cocco, Lucia Manzoli, Irene Faenza, Giulia Ramazzotti, Yong Ryoul Yang, James A McCubrey, Pann-Ghill Suh, Matilde Y Follo. Modulation of nuclear PI-PLCbeta1 during cell differentiation. Advances in biological regulation. 2016 Jan;60:1-5


    PMID: 26525203

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