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The consumption of carbosulfan-contaminated rice affects the immune and lymphocyte response, germinal centers in the spleen, plasma cells in popliteal lymphoid nodes, bone marrow cells and granulocyte-macrophage progenitor cells. Towards this, a highly sensitive acetylcholinesterase (AChE) cyclic voltammetric biosensor based on zinc oxide (ZnO) nanocuboids modified platinum (Pt) electrode has been successfully developed. The Pt/ZnO/AChE/Chitosan bio-electrode was employed for the electrochemical detection of carbosulfan in rice sample. Under optimum conditions, the Pt/ZnO/AChE/Chitosan bio-electrode detected carbosulfan ranging from 5 to 30 nM with a detection limit (LOD) of 0.24 nM. The developed Pt/ZnO/AChE/Chitosan bio-electrode showed good recovery (99.06-100.96%), thus providing a promising tool for analysis of carbosulfan in rice sample. Copyright © 2015 Elsevier B.V. All rights reserved.


Noel Nesakumar, Swaminathan Sethuraman, Uma Maheswari Krishnan, John Bosco Balaguru Rayappan. Electrochemical acetylcholinesterase biosensor based on ZnO nanocuboids modified platinum electrode for the detection of carbosulfan in rice. Biosensors & bioelectronics. 2016 Mar 15;77:1070-7

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PMID: 26562329

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