Nwet Nwet Win, Takuya Ito, Ismail, Takeshi Kodama, Yi Yi Win, Masami Tanaka, Hla Ngwe, Yoshinori Asakawa, Ikuro Abe, Hiroyuki Morita
Journal of natural products 2015 Dec 24Seven new tetracyclic quassinoids, picrajavanicins A-G (1-7), along with three known analogues, were isolated from a CHCl3-soluble extract of the bark of Picrasma javanica collected in Myanmar. The structures of these compounds were elucidated using spectroscopic techniques, including 1D and 2D NMR. The absolute configuration at C-2 of 2 was determined to be S by the modified Mosher method. All the isolates were tested for their antiproliferative activities against a small panel of five human cancer cell lines. However, none of the isolated compounds exhibited inhibitory activity against any of the cancer cells used (IC50 values >10 μM).
Nwet Nwet Win, Takuya Ito, Ismail, Takeshi Kodama, Yi Yi Win, Masami Tanaka, Hla Ngwe, Yoshinori Asakawa, Ikuro Abe, Hiroyuki Morita. Picrajavanicins A-G, Quassinoids from Picrasma javanica Collected in Myanmar. Journal of natural products. 2015 Dec 24;78(12):3024-30
PMID: 26606140
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