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    Seven new tetracyclic quassinoids, picrajavanicins A-G (1-7), along with three known analogues, were isolated from a CHCl3-soluble extract of the bark of Picrasma javanica collected in Myanmar. The structures of these compounds were elucidated using spectroscopic techniques, including 1D and 2D NMR. The absolute configuration at C-2 of 2 was determined to be S by the modified Mosher method. All the isolates were tested for their antiproliferative activities against a small panel of five human cancer cell lines. However, none of the isolated compounds exhibited inhibitory activity against any of the cancer cells used (IC50 values >10 μM).


    Nwet Nwet Win, Takuya Ito, Ismail, Takeshi Kodama, Yi Yi Win, Masami Tanaka, Hla Ngwe, Yoshinori Asakawa, Ikuro Abe, Hiroyuki Morita. Picrajavanicins A-G, Quassinoids from Picrasma javanica Collected in Myanmar. Journal of natural products. 2015 Dec 24;78(12):3024-30

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    PMID: 26606140

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