Aryl Polyenes, a Highly Abundant Class of Bacterial Natural Products, Are Functionally Related to Antioxidative Carotenoids.

Tim A Schöner, Sören Gassel, Ayako Osawa, Nicholas J Tobias, Yukari Okuno, Yui Sakakibara, Kazutoshi Shindo, Gerhard Sandmann, Helge B Bode

Chembiochem : a European journal of chemical biology 2016 Feb 2

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Bacterial pigments of the aryl polyene type are structurally similar to the well-known carotenoids with respect to their polyene systems. Their biosynthetic gene cluster is widespread in taxonomically distant bacteria, and four classes of such pigments have been found. Here we report the structure elucidation of the aryl polyene/dialkylresorcinol hybrid pigments of Variovorax paradoxus B4 by HPLC-UV-MS, MALDI-MS and NMR. Furthermore, we show for the first time that this pigment class protects the bacterium from reactive oxygen species, similarly to what is known for carotenoids. An analysis of the distribution of biosynthetic genes for aryl polyenes and carotenoids in bacterial genomes is presented; it shows a complementary distribution of these protective pigments in bacteria. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Tim A Schöner, Sören Gassel, Ayako Osawa, Nicholas J Tobias, Yukari Okuno, Yui Sakakibara, Kazutoshi Shindo, Gerhard Sandmann, Helge B Bode. Aryl Polyenes, a Highly Abundant Class of Bacterial Natural Products, Are Functionally Related to Antioxidative Carotenoids. Chembiochem : a European journal of chemical biology. 2016 Feb 2;17(3):247-53