Excited-State Dynamics of a Two-Photon-Activatable Ruthenium Prodrug.

Simon E Greenough, Michael D Horbury, Nichola A Smith, Peter J Sadler, Martin J Paterson, Vasilios G Stavros

Chemphyschem : a European journal of chemical physics and physical chemistry 2016 Jan 18

filter terms:

We present a new approach to investigate how the photodynamics of an octahedral ruthenium(II) complex activated through two-photon absorption (TPA) differ from the equivalent complex activated through one-photon absorption (OPA). We photoactivated a Ru(II) polypyridyl complex containing bioactive monodentate ligands in the photodynamic therapy window (620-1000 nm) by using TPA and used transient UV/Vis absorption spectroscopy to elucidate its reaction pathways. Density functional calculations allowed us to identify the nature of the initially populated states and kinetic analysis recovers a photoactivation lifetime of approximately 100 ps. The dynamics displayed following TPA or OPA are identical, showing that TPA prodrug design may use knowledge gathered from the more numerous and easily conducted OPA studies. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Simon E Greenough, Michael D Horbury, Nichola A Smith, Peter J Sadler, Martin J Paterson, Vasilios G Stavros. Excited-State Dynamics of a Two-Photon-Activatable Ruthenium Prodrug. Chemphyschem : a European journal of chemical physics and physical chemistry. 2016 Jan 18;17(2):221-4