Correlation Engine 2.0
Clear Search sequence regions

  • aldehydes (5)
  • catalysis (1)
  • hydrogen (1)
  • phosphites (2)
  • pyruvates (4)
  • Sizes of these terms reflect their relevance to your search.

    An organocatalytic three-component reductive coupling reaction between dimethyl phosphite, benzylidene pyruvates, and aldehydes is reported. A chiral triaryliminophosphorane catalyst promotes Pudovik addition, which is followed by phospha-Brook rearrangement to transiently generate enolates that are trapped stereoselectively by aldehydes. This reductive coupling provides vicinal polyfunctionalized stereocenters from readily available prochiral starting materials with excellent diastereoselectivity, enantioselectivity, and yield.


    Matthew A Horwitz, Blane P Zavesky, Jesus I Martinez-Alvarado, Jeffrey S Johnson. Asymmetric Organocatalytic Reductive Coupling Reactions between Benzylidene Pyruvates and Aldehydes. Organic letters. 2016 Jan 4;18(1):36-9

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 26667068

    View Full Text